Reaction conditions are critical poor pH and/or temperature control results in both decarboxylation of 2-carbomethoxytropinone to tropinone (which is, in turn, reduced to tropine and pseudotropine) and C-2 epimerization of methyl ecgonine to pseudoecgonine methyl ester. In step two, the 2-carbomethoxytropinone is dissolved in a minimal volume of ice-cold dilute sulfuric acid and reduced to methyl ecgonine with a 1 to 1.5% Na/Hg amalgam at pH 3.5 and 5☌. Enantiomeric resolution of the racemate can be accomplished at this point with (+)- and (-)-tartaric acid however, as noted above, none of the operators of the three clandestine laboratories seized to date attempted such a resolution. After 2 days, the reaction mixture is made basic and extracted with chloroform to give racemic 2-carbomethoxytropinone tropinone is the major impurity. The first step involves a ring coupling Mannich reaction using methylamine, succindialdehyde, and acetonedicarboxylic acid monomethyl ester in high dilution in a buffered, aqueous solution at 25☌. Two of these laboratories were run by clandestine operators with advanced chemical training, and successfully produced very low yields of racemic cocaine.
All three followed the classic synthesis however, none of the three performed the enantiomeric resolution step. To date, there have been only three seizures of illicit synthetic cocaine laboratories in the United States. The synthesis will produce a pair of racemic diastereomers (of which only one, i.e., (-)-cocaine, is physiologically active) if the enantiomeric resolution and diastereomeric purification steps are omitted. The classic total synthesis of cocaine involves three synthetic, one enantiomeric resolution and one diastereomeric purification steps (Figure 112,22), and requires a significantly high level of synthetic expertise and well-equipped laboratory facilities. unfourtunetly, he died and untimely death and never investigated the matter as far as I know. He said the "bucket method" resulted in a higher % of Tropacocaine, and that Tropacocaine was the problem, not cocaine per se. we used to talk, and he told me that the insanity part of coke came with the switch in manufaturing. I knew this guy with a Ph.D who worked in columbia. Later, "rock" or "crystal" was massively produced in containers, from buckets to oil drums, and crystalized from the solvent-of-the-day- the coke fun thing went to hell. When coke HCL started getting big, it was generally crystalized from di-ethly ether on bed sheets hanging on lines. The quality of the product is largely dictated by the various alkailoid ratios present in the leaf. Thier is no aspect of cocaine I have not been involved with. I know all about coke farms and labs, from personal experience. And all the Merck stuff was 100% (within the margin of Uncertainty- it melted like a snow flake on a hot plate). Some was built from scrath ( I knew a guy who knew a guy. Let the water and crack-blob cool, then remove the hardened mass.Click to expand.Not all of it. To remove the bubble air-pockets in the crack rock, simply add more water into the glass container and reheat the mixture until you have a solid yellow crack-blob floating in the water. Once the mix starts to boil, remove from heat and let the mixture cool.Īfter cooling, it should be a mass of hardened crack that still has bubbles of air-pockets in it from boiling. Heat the bottom of the container, evenly, until the entire mixture begins to boil.
Make sure they are chopped into fine powder and mixed well, then combine them into the glass container.Īdd a few drops of water until the mixed powder becomes like thin mud Mix cocaine and baking soda at a 4:1 ratio (4 parts cocaine to one part baking soda). A lighter, or gas stove top, or other open flame.Baking soda, flower, corn starch, pancake mix.
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